injection device

专利摘要:

公开号:DK201000203U1
申请号:DK201000203U
申请日:2010-10-29
公开日:2010-11-12
发明作者:Schwirtz Andreas；Csenar Markus
申请人:Pharma Consult Ges M B H & Co；
IPC主号:

专利说明:

- 1 - DK 2010 00203 U4
IniektionsanordmnQ
The invention relates to an injection device, in particular an auto-injector, for delivering a medicament as described in claim 1.
From US 6,767,336 B1 there is known an automated injection device for delivering a medicament comprising a carrier housing in which the drive unit, the storage container for the medicament as well as the needle device are placed. An elastically deformable and piercable protective member connected to the needle holder is threaded over the needle of the needle assembly. The needle holder on one side carries the needle and is coupled to the storage container for the drug at its distal end. The cannula always has a flow connection to the inner compartment and thus to the drug. In the region at the distal end, a needle guard element is provided with a longitudinally displaceable member to which an additional propellant is assigned. At the proximal end of the carrier housing, a release sleeve is assigned to this, respectively, which accommodates the carrier housing at least regionally. In addition, a securing element is assigned to the first drive unit so that an unintended trigger is avoided. The release of the needle guard element or its propellant, respectively, takes place during the relative displacement of the drug container with the needle device placed thereon. Both the release sleeve and the needle guard element are each disposed in close proximity and one after the other in axial direction on the common carrier housing.
From EP 0 307 367 B1 and from DE 38 72 122 T2, respectively, there is known an injection device for delivering a medicament by which the medicament can be taken up by withdrawal in the syringe barrel. A needle guard device located on the outside of the syringe barrel is actuated by a cone-shaped member on the piston rod. In connection with the spraying and in connection with the delivery of the drug, respectively, the securing device is released by means of the cone-shaped part, with the outer needle protection sleeve, under the influence of a spring force, being adjusted along the spray cylinder until the needle protruding past the spray cylinder is covered.
From US 5,295,965 A and the parallel EP 0 620 748, respectively, there is known an automated injection device with a housing for dispensing a medicament, in which the outer enclosure constitutes a needle protective sleeve. This extends from the distal end facing the patient to the proximal end and can be activated there with a sheath-shaped release sleeve. For activation, a locking pin must be released which is located in the region at the proximal end and which secures the first drive unit until the release which is made with the sheath-shaped release sleeve. Once the locking pin is removed, the sleeve-shaped release sleeve can be moved relative to the carrier housing as well as the needle guard housing, thereby releasing both the first drive unit and the needle guard housing. The needle protection sheath is, for its part, provided with its own spring device, by means of which it is adjusted to the position where the needle is covered. In this connection, the needle protection sheath has a flat front wall which extends from the sides of the needle protection sheath and in connection with the application lies across the longitudinal axis of the injection device. After delivery of the drug and after the completion of the injection process, the needle guard sheath is held fixed relative to the housing in the position where the needle is covered.
From US 5,658,259 A and from EP 0 956 058 B1, respectively, there is known a further automated injection device for delivering a drug from a carpule. For this purpose, the carpule with the drug is placed within a carrier housing, and in this connection a further first drive unit is assigned to the carpule for activating it and delivering the drug. Inside the carrier there is a needle guard, which can be released by a length adjustment of the needle holder, and which an adjusting element is also assigned. The needle guard sheath is held within the support body by means of an engagement joint until it is released by the adjustable needle holder. After delivery of the drug, the needle protection sheath covers the end of the needle protruding past the auto-injector.
US 4,031,893 A discloses a further auto-injector in which the drive unit which can be released and the drug container with the needle device placed thereon is accommodated in a common carrying case. The drive unit is again secured by means of a securing element against an unintended release. The bearing housing is surrounded on its exterior by a casing-shaped structural element, which at its proximal end is coupled to a further release casing. When the fuse cover is removed together with the fuse pin, the release sheath causes a release of the drive unit, thereby aligning the drug container with the needle device towards the distal end. The cannula, which always has a flow connection to the inner compartment of the drug container, is surrounded by an elastically deformable protective sheath which is supported on the inside of the distal end of the carrier housing. In connection with the forward movement, the cannula pierces the elastically deformable protective cap and exits the carrier housing for injection. The elastically deformable needle protection sheath, after completion of the injection process, causes the needle device to be reset together with the drug container to the inner compartment of the carrier.
The object of the present invention is to provide an injection device, in particular an auto-injector which, in connection with a simple operation, has a high operational safety, in particular an improved protection of the needle.
This purpose for the production is achieved by the bearing housing being extended over the greater part of its longitudinal extension between the distal and the proximal end of the actuating sheath, and the needle guard element, together with the other drive unit cooperating with it, is placed in an axial section. radial direction between the bearing housing and the activating sheath.
The surprising advantage that arises from the features of claim 1 is that the actuation sleeve also accommodates the drive unit assigned to the needle guard member, thereby safely avoiding manipulations for a possible subsequent use. Furthermore, through the overall bearing in the storage position, however, a manipulation is also avoided at the drive units as well as at the needle protection element. In addition, however, further protection of all interior structural members is also achieved as a result of the almost complete coverage by means of the activating sheath. In addition, due to the simple operation, malfunctioning is practically excluded and no further adjusting or release movements are needed in order to initiate delivery of the drug. A further advantage also lies in the fact that, after the release thereof, the actuating and actuating sleeve, respectively, by means of the securing device of the user with a single-handed operation can be easily transferred to the place on the body where the delivery is to take place, simultaneously with the entire injection device, and that a corresponding support of the support housing for the injection device at this location on the body and a corresponding pressure connection can achieve a relative displacement of the activation housing relative to the support housing. Thereby, the drug delivery process is initiated and implemented. Thus, the entire injection device can be prepared for the subsequent dispensing process only by removing the fuse cover of the fuse device and the drug after initiation with a single additional pressure movement via the activating sheath being dispensed automatically to that particular location on the body.
Also advantageous is the production according to claim 1, since according to this, by separating the carrier housing into two carrier parts which can be displaced relative to each other, different operating states can be obtained which are of crucial importance in connection with sterilization and the subsequent storage time.
Also advantageous is a design according to claim 2, since according to this an additional guide is provided between the support housing parts to be coupled, while at the same time further pre-defined coupling positions can be provided in this area.
By means of the design according to claim 3, it is possible already to obtain a clear positioning of the two support housing parts in the first coupling position and furthermore create the possibility of an external approach to the front support housing part in this position.
According to another embodiment according to claim 4, only one direction of movement of the two support housing parts is possible towards one another, while an undesirable separation, for example due to shaking and impact loads, etc., is prevented in a safe way.
Also advantageous is a further development according to claim 5, since the carrier housing according to this at its distal end also permits a piercing through the sealing plug, however, by means of which a sterile closure of the front holding space in connection with the front carrier housing part is ensured during the entire storage time.
In the design according to claim 6, it is advantageous that according to this at a predetermined location an approach necessary for the sterilization, which takes place at a later stage, can be provided to the front recording round, thus that the needle device contained respectively contained therein may also be sterilized by an already pre-assembled injection device.
By means of the further development according to claim 7, it is achieved that a predetermined impact area can be provided on one side for the sealing element and on the other side for the support for the other drive unit.
By means of the design according to claim 8, after the sterilization has been performed, a clear and secure seal of the sterilized front recording space can be made. In addition, the circumferential sealing member may also serve as a cushioning holder for the carpule contained in the carrier housing along with the drug. In this way, the shock and impact loads from the external activating sheath and to the carpule with the drug can be attenuated or completely reduced or absorbed respectively.
Also advantageous is a design according to claim 9, since only a predefined internal space for the sterilization is used for the gas sterilization in connection with the ETO sterilization.
According to a design as described in claim 10, since, in connection with the already pre-assembled injection device, there can nevertheless be provided between the individual structural elements an approach to the front storage space for the sterilization to be carried out subsequently.
In this connection, a design according to claim 11 is found to be advantageous, since according to this a short adjustment path between the two support housing parts after sterilization, an impeccable seal can also be obtained over a longer storage time.
According to an advantageous further development according to claim 12, it is only possible to slide the activating sheath and the carrier housing into each other respectively over one another, while preventing an undesirable separation of the two parts from one another in a safe way. This provides a very high level of reliability and manipulations are virtually excluded.
Advantageously, however, is also a configuration according to claim 13, since according to this a control surface which can be uniquely determined in advance and after a relative adjustment path which can be predetermined, between the actuating housing and the carrier housing, a release or activation of the needle protection element is also effected. . This is adjusted to the position where the cannula is covered after use by means of the second drive which cooperates with it.
According to claim 14, therefore, a unique position fixing between the needle guard element and the carrier housing is achieved during the storage position. This fixation can be released by a simple swinging movement of the arm element, for this purpose a relative length adjustment between the carrier housing and the activating sheath is required, the adjustment of the rib-like arm element and thus the release of the needle guard element being carried out in cooperation with the abutment surface. is designed on the activation sleeve.
In the design according to claim 15, a new reset is prevented and in connection therewith a new release of the needle tip already used on the cannula.
In this connection, there is also the possibility of a configuration according to claim 16, since according to this a further mechanical fixation of the needle protection element between the carrier housing and the activating sheath is made.
The design according to claim 17 allows a stop restriction of the forward movement of the needle guard member to the covering position. Thereby, the adjusting forces of the propellant on the second drive unit can be selected somewhat higher so as to in any case safely achieve an impeccably covering position.
Advantageously, the design according to claim 18 is, since according to this a prefabricated unit can be provided which can be placed on the carpule or held thereon respectively. This assembled needle device is dimensioned in such a way that the needle tip facing the carpule or the carpal closure, during the entire storage position, has not yet penetrated the carpal latch, so that a medicament stored in the carpal cannot expire. The flow connection between the cannula and the inner compartment of the carpule is first established during the injection process.
Advantageously, however, is also a configuration according to claim 19, since the needle holder thereof can be held in a uniquely defined positioning relative to the guide element, and the flow connection between the cannula and the inner compartment of the carpule is established only after a predetermined setting path for the carpule. relative to the bearing housing.
However, there is also the possibility of a design, as described in claim 20, since the process of inserting the needle end through the carpal closure, in conjunction with a control curve according to it, is first performed at a location that can be defined in advance or according to a setting path, respectively. can be determined in advance, thereby providing an approach to the drug to be delivered.
Advantageously, the design according to claim 21 is, since, by means of the reduction of the dimension in the region of the piston rod, a greater distance to the inner wall of the carpule is obtained, whereby in connection with a impact load a damage to the carpule can be prevented.
Also advantageous is a further embodiment according to claim 22, since the injection process, which is performed automatically after the triggering and activation of the drive unit, respectively, can be triggered with a unique short adjustment path between the actuating sheath and the carrier housing.
- 6 - DK 2010 00203 U4
Also advantageous is a configuration according to claim 23, since on the one hand the time of insertion in the patient and on the other hand the establishment of the flow connection to the inner space of the carpule according to it can be determined during the relative length adjustment of the entire needle unit with the carpule.
By means of the configuration according to claim 24, it is possible to first obtain a safe insertion of the cannula into the patient and only subsequently establish the access to the drug. This prevents the drug from accidentally running out of the needle even before inserting the cannula onto the patient.
According to another embodiment according to claim 25, a high operating safety is achieved at the entire injection device, since the needle guard to the position where the used cannula is covered is activated even when the first drive unit is activated.
Also advantageous is a further development according to claim 26, since a simultaneous release thus takes place with a single instituting movement, whereby a covering of the needle tip protruding past the carrier housing, in connection with a possible malfunction, is also carried out safely before the drug is dispensed.
In addition, a design, as described in claim 27, is also advantageous, since a slim construction method is sufficient and a relatively accurate length guide of the needle protection element on the carrier can also be obtained.
However, there is also the possibility of a design, as described in claim 28, since according to this a relative positioning of the holding arms relative to the holding disc is made, thereby preventing a mutual squeezing in a safe way. In addition, in this way an even more secure effect can be obtained on the entire device of the first drive unit.
In connection with the preparation of the injection device, the injection device, prior to its sterilization, can be completely enclosed by a bacteria-tight enclosure which is gas permeable to a gas sterilization by means of ethylene oxide. Thus, in the manufacturing situation, a sterilization independent of the mounting is allowed, without which, after sterilization, impurities can again be released into the not yet completely enclosed sterilized recording space around the needle device.
In connection with the manufacture of the injection device, the injection system may, prior to its sterilization, be accommodated in a vessel-shaped receptacle which is closed in the region of a container rim by a bacterial-tight cover which is, however, gas permeable to a gas sterilization by of ethylene oxide.
Thereby, in the manufacturing situation, several such injection devices can be stored in a side-by-side location. In addition, in the manufacturing situation, a sterilization which is independent of the mounting is also possible, without which, after sterilization, impurities can again be released into the not yet completely closed sterilized recording space around the needle device.
For the preparation of the injection system, the encapsulation or cover may be selected from a high density polyethylene (HDPE) high density polyethylene fiber textile textile fabric. In this way, a material is used which, according to the current standards, also enables a germ-free or sterile storage over a longer storage period.
In connection with the manufacture of the injection device of the present invention, it can be sterilized by using a method of sterilizing an injection device, in particular an auto-injector, comprising the following steps: • Designing a carrier housing comprising a front and a rear carrier portion, the two carrier portions of a connecting section are coupled to one another via a coupling device of its length to two different length positions; Designing a passage in the connection section of the two support housing portions to produce a flow interconnect with at least one take-up space for the two support housing portions in the first connected longitudinal position; • Positioning a carpule with a medicament contained therein, a needle device located in front of the carpule, as well as a drive unit cooperating with the carpule, in the carrying case; • Closing an aperture formed at the distal end of the front body portion and for passage of a needle end of a cannula, with a sealing plug that can be pierced, in a sealing position with the body portion; • Placing an orbital sealing member in the connection section of the two carrier housings; Performing the sterilization of at least one containment compartment formed in the carrier housing and sealed, and of the needle device incorporated therein with a gas sterilization by means of ethylene oxide via the passageway formed in the connection section; Disconnecting the flow connection between the sterilized recording compartment and the external environment through the passage formed in the connection section, the sealing element being brought into sealing connection both at an end facing the front carrier housing of the rear carrier housing and at an inner surface of the front bærehusdel.
- 8 - i - 8 - i j DK 2010 00203 U4
Other advantages of the production are that an injection device with all its structural elements can be prefabricated and mounted to such an extent that, with very limited effort, a completely closed enclosure can be provided within the injection device. Due to the separation of the carrier housing into the two carrier housing portions, 5 after sterilization, by an appropriate interruption of the flow connection, an absolutely sterile state of the structural elements intended for insertion can be ensured. This is accomplished by very simple means without the need for additional closure elements.
Other advantages are that an injection device with all its structural elements can thus be prefabricated and mounted to such an extent that, with very limited effort, a completely closed enclosure can be provided within the injection device. By this injection device, the entire needle device can be sterilized as the internal space surrounding the needle device, thereby maintaining this sterile condition in a safe manner throughout the storage period. This is achieved with very simple means without the need for an additional 15 sealing elements.
In addition, it is advantageously possible that the disconnection of the flow connection is effected by a displacement of the two support housing portions towards each other to the second coupled longitudinal position. This is because thus (according to this only with the aid of a relatively short axial displacement of the front and rear carrier parts relative to each other) a fully enclosed recording space is realized.
It is advantageous when the circumferential sealing element in connection with the displacement of the two support housing parts is brought into contact by a front wall formed in the connection section to the front support housing part and inwards towards the longitudinal axis and the flow connection via the passage formed in the thus interrupting the access to the sterilized recording space, on the one hand, is safely prevented and in this fixed position can also be retained for a long storage time.
It is also possible for the sealing element to be sealed in contact with an external surface of the carpule, since the inner space to be sealed can thereby be reduced, and in addition a resilient support of the carpule relative to the carrier housing is obtained.
It is also advantageous when, prior to the sterilization, the injection device is completely enclosed by a bacteria-tight enclosure which is, however, gas permeable to a gas sterilization by ethylene oxide, thereby allowing a sterilization independent of the sterilization without thus, after sterilization again, impurities can enter the not yet completely enclosed sterilized recording space around the needle device.
40 It is also advantageous when, prior to the sterilization, the injection device is placed in a vessel-shaped receptacle, and the receptacle in the region of a container rim is closed by a bacterial-tight cover which is, however, gas permeable to a gas sterilization by of ethylene oxide since several such injection devices can be stored in a side-by-side location. In addition, a sterilization which is independent of the mounting is also possible, without which, after sterilization, impurities can again be released into the not yet completely enclosed sterilized recording space around the needle device.
Finally, it is also possible that the enclosure or cover is selected from a high density polyethylene (HDPE) paper fiber-like fiber feature textile. The advantage of this is that a material is used which, according to the current standards, also enables a germ-free or sterile storage over a longer shelf life.
For a better understanding of the production, this is explained in more detail on the basis of the following figures.
A highly schematic simplified view is shown, respectively:
FIG. 1 shows an injection device designed according to the prior art prior to sterilizing the recording space with the needle device located therein in an axial section and in simplified view;
FIG. 2 shows a sub-region of the injection device according to FIG. 1, however, in relation to this second section plane;
FIG. 3 shows the injection device according to figures 1 and 2 in an already sterilized state in an axial section and a simplified view;
FIG. 4 the injection device of Figures 1 to 3 during the delivery process for the drug in an axial section and simplified imaging;
FIG. 5 shows the injection device of Figures 1 to 4 at a position of the needle guard member covering the cannula in an axial section and simplified view;
FIG. 6, however, the injection device according to FIG. 5, in relation to this second section plane;
FIG. 7 is a top view of the retaining plate of the securing device in a simplified view;
FIG. 8 the injection device according to the embodiment of Figure 1 before, respectively, during sterilization in a recording bowl intended for this purpose in a sectional view according to lines VIII - VIII of Figure 10;
FIG. 9 shows the injection device according to Figure 8 in the receiving bowl in the coupling position after the sterile ring in the fully sealed position; - 10 - DK 2010 00203 U4
FIG. 10 is a partial section of the recording bowl of Figures 8 and 9 in a schematic simplified view, without the injection device;
FIG. 11 shows the needle device in the engaged position on the carpule of Figures 1 to 6 in a schematic simplified view;
FIG. 12 the needle assembly of FIG. 11, wherein the guide member of the guide member is lifted off, in a schematically simplified view;
FIG. 13 the needle device in the engaged position of the carpule of FIGS. 1 to 6 during the adjustment movement for delivery of the drug in a position immediately prior to the interaction between the adjustment cushion and the control curve in an axial section;
FIG. 14 is a first pre-assembled unit for the injection device in the region of the front support body portion in an axial section;
FIG. 15 shows a further pre-assembled unit for the injection device in the region of the rear carrier portion in an axial section.
Initially, it is to be noted that in the variously described embodiments, identical parts are provided with the same reference numerals or the same component names, respectively, since the presentations contained in the overall description can be transferred to identical parts with the same reference numerals and with the same component designations according to to the meaning. The position indications selected in the specification, e.g. The top, bottom, next, etc. also relate to the immediately described and shown figure and, in connection with a change of position, must be transferred to the new position according to the meaning. In addition, single features or combinations of features from the various exemplary embodiments shown and described may also present in themselves independent production solutions or solutions according to the invention.
All particulars of value ranges in specific description must be understood in such a way that they also include arbitrary and all sub-areas thereof, e.g. the indication 1 to 10 is to be understood in such a way that all sub-areas based on the lower limit 1 and the upper limit 10 are also included, ie. all subareas begin with a lower limit of 1 or higher and end at an upper limit of 10 or lower, e.g. 1 to 1.7 or 3.2 to 8.1 or 5.5 to 10.
In Figures 1 to 6, an injection device 1, in particular an auto-injector, is shown simplified in different operating positions. In such autoinjectors used for the automated delivery of a drug, a so-called storage position and an injection position are distinguished, since there are automated adjustment and displacement processes between these two positions in which the delivery of the drug is taken.
The injection device 1 is composed of a large number of structural elements and may comprise a carrier housing 2, a storage container accommodated therein, such as a carpule 3, a first releasable drive unit 4, which has an effective connection to the carpule 3, a securing device 5, a needle device 6, a needle guard element 7 as well as another drive unit 8, which is associated with the needle guard member 7, respectively, have an effective connection thereto, as well as an activating sleeve 9.
10
The injection device 1 and the carrier housing 2, respectively, have a distal end 11 facing a living creature such as a patient 10, as well as a proximal end 12 facing away from it, a longitudinal axis 13 extending between the two ends 11, 12. In addition, the designation of the position indication is used first and foremost, and in this connection, the distal end 11 and 15 are at the rear the proximal end 12. Here, the receptacle for a drug 14 is formed by the carpule 3, in which the drug 14 and the active substance respectively is delivered and injected, stored under the storage position and ready for delivery. In this connection, the carpule 3 is accommodated in the bearing housing 2 and surrounded by it respectively. As for the carpule 3, these are ordinary packages for the medicament 14, the amount of the medicament 14 contained therein being adapted to the application according to the case of use. In addition, the first drive unit 4 that can be released, as it is known, is assigned to the carpule 3 at the end facing the proximal end 12 of the injection device 1, respectively, having an effective connection thereto.
The first drive unit 4 comprises a first drive means 15 which is secured against release by means of the securing device 5 until a user deliberately activates the injection device 1, in connection with which the first drive unit 4 is released and the injection device 1 is thereby released. Due to the securing device 5, the first drive unit 4 is incorporated. it is activated for the injection process, fixed in its position with respect to the carrier housing 2. The first drive unit 4, in particular 30 the propellant 15 and the holding arms 16, assigned to the propellant 15, are accommodated within the carrier housing 2. The holding arms 16 intervene in a holding disc 17 located in the region at the proximal end 12 of the injection device 1, the detailed description of which is given below. In addition, as a measure against an unintended release of the drive unit 4, the securing device 5 comprises a securing cap 18, and in this connection there is placed in its center 35 a securing pin 19 which projects through the holding disc 17. The securing pin fixes in a known manner in the radial direction relative to the to the longitudinal axis 13 and, until the fuse cover 18 is removed together with the fuse pin 19, prevents the retaining arms 16, which are retained locked on the retaining disc 17, in a radial direction against the longitudinal axis 13.
40 In the region at the distal end 11, the needle assembly 6 is located immediately in front of the carpule 3. The needle assembly 6, for its part, comprises a cannula 20 or a hollow-shaped needle, respectively, with needle ends 21, 22 spaced in the direction of longitudinal axis 13. .
- 12 - DK 2010 00203 U4
The cannula 20 is held by a needle holder 23, respectively, contained therein. Both needle ends 21, 22 each extend beyond the needle holder 23 on both sides.
The needle holder 23, for its part, is connected via a ferrule member 24 to a carpule end 25 facing the distal end 11, respectively, connected therewith. Further details of this can be seen in the following figures 11 and 12. The carpule 3, for its part, at the carpule end 25 facing the distal end 11, contains a carpal closure 26 which can be pierced. The proximal needle end 22 facing the carpal closure 26 is provided with the needle holder 23 on the guide member 24 in such a way that the needle end 22 in the storage position of the injection device 1 is still at a distance from the carpal closure 26. Thus, an access to the carpal 3 is provided. internal and to the drug 14 initially prevented. In addition, both needle ends 21, 22 in the storage position of injection device 1 are located within the carrier housing 2, thereby preventing puncture damage. In addition, as explained below, the entire needle assembly 6 can also be kept in a completely sterile state throughout the storage period until the intended use at which the drug 14 is dispensed.
The needle guard element 7, which has an effective connection to the second drive unit 8, can by means of this be shifted from a non-operative position to a position where the needle end 21 extending after the injection process past the distal end 11 of the carrier housing 2 is covered. The release of the second drive unit 8 as well as the adjustment of the needle guard element 7 is also described in detail below. The needle guard element 7, together with the second drive unit 8, is located in the area at the outside of the carrier housing 2 and at least regionally supported thereon.
The carrier housing 2 is further surrounded by the greater part of its longitudinal extension between the distal end 11 and the proximal end 12 of the activation sleeve 9 described above. In this connection, only the distal end 11 of the carrier housing 2 protrudes past the actuation sleeve 9 in the axial direction. Here, the term "over the greater part" of its length is understood to mean that, in relation to the length of the carrier housing 2, the activating sheath 9 extends over a length extending from a lower limit of at least 50% to an upper limit of up to 100%. In this connection, values for the length extension of at least 50%, preferably of at least 60%, especially of at least 70%, preferably of at least 80%, preferably of at least 90%, are particularly preferred of at least 60%. At least 95% advantageous, since almost all of the carrier housing 2 is respectively received by the activating sheath 9, the needle guard element 7 with the second drive unit 8 cooperating therewith is seen in an axial section located in a radial direction between the carrier housing 2 and the actuating casing 9. Thereby the second drive unit 8 cannot be actuated for a release or deactivation thereof, the actuating casing 9 can also be referred to as a release casing. it serves this not only for the function consisting in activating or releasing the first drive unit 4, but also for the user to be able to keep the entire injection device 1 and also remain unchanged throughout the delivery process.
- 13 - DK 2010 00203 U4 The carrier housing 2 comprises, for its part, a front and a rear carrier housing 27, 28, and in this connection the front carrier housing 27 faces the distal end 11 and thus the patient 10. The rear carrier housing 28 is positioned thus; that it is closer to the proximal end 12. The two support housing portions 27, 28 define respectively a front and a rear receiving space 29, 30 and can be connected in a connecting section 31 located therebetween via a coupling device 32 with each other in the direction of longitudinal axis 13 in two longitudinal positions which are different from each other in a first and a second coupling position.
In Figure 1, the first coupling position is shown, and in this connection the two support housing parts 27, 28 have a greater longitudinal extension in the direction of the longitudinal axis 13 relative to the second coupling position. In addition, it is further seen that the front support member 27 engages the rear support member 28 in the connecting section 31 and the coupling device 32 located there.
The coupling device 32 includes at both carrier parts 27, 28 locking elements 33, 34 which in each case cooperate with each other and which are designed in such a way that the two carrier housing parts 27, 28 in the two coupling positions are fixed in each case in each case. one relative to each other in the direction of movement. By opposite direction of movement is meant here a fixation which prevents the two support housing parts 27, 28 from moving away from each other in the direction of the longitudinal axis 13, but nevertheless allows movement towards each other from the first coupling position to the second coupling position.
For example, the first locking members 33 of the coupling device 32 are formed in the region of the front carrier part 27 by recesses or openings in the wall of the front carrier part 27. Preferably, in the axial direction, for the two coupling positions, several locking elements 33 are provided. each other. The latching element or locking members 34 of the coupling device 32 on the rear carrier part 28 can be formed by means of engagement noses and engagement projections, respectively, which engage in the recesses and the breakthroughs, preferably again in the direction of longitudinal axis 13 several of these locking elements 34 are provided. coupling position, in which the two support housing parts 27, 28 have a greater length extension than in the second coupling position, in each case only the front locking members 34 are engaged with the rear locking elements 33 on the front carrier part 27. The second coupling position is in Figure 3 shown in another section plane rotated with respect to Figure 1. In this connection, in the second coupling position, in each case, the two locking members 34, located one after the other, on the rear carrier part 28 engage the corresponding locking elements 33 on the front bearing body portion 37. Thus, ib in two positions, the two support housing parts 27, 28 move away from each other.
In the region at the distal end 11, the carrier housing 2 and the front carrier housing portion 27, respectively, are provided with an opening 35 which permits the passage of the end 21 of the needle device 6. In this opening 35 a sealing plug 36 which can be pierced is placed in a position. which seals the front recording space 29 relative to the external environment.
- 14 - DK 2010 00203 U4
The front carrier part 27 contains in the connecting section 31 to the rear carrier part 28 at least one passage 37 which allows access from the outside of the carrier housing 2 at least to the front receiving space 29 with the needle device 6 located therein. located respectively provided in the wall section of the front carrier portion 27 which engages the rear carrier portion 28. Immediately adjacent to the passageway or passageways 37, respectively, the connecting portion 31 engaging the rear carrier portion 28 engages a wall portion 38 inwardly against the longitudinal axis 13, and preferably positioned so as to extend in a plane oriented perpendicular to the longitudinal axis 13. This wall portion 38 has a front wall 39 facing the rear carrier portion 28 and is also positioned so as to extend into a plane. a plane oriented perpendicular to the longitudinal axis 13. On the wall portion 38, the second drive unit 8 is included a further propellant 40 further supported on the side facing away from the rear carrier portion 28. The propellant 40 may again be formed by a biased compression spring or a similar spring element.
In addition, on the inward front wall 39 of the wall part 38 there may be placed a shoulder 41 which, in axial section, is designed in wedge shape and is designed so that it is continuous over the scope. In this connection, the wedge-shaped taper is directed towards the rear carrier portion 28.
On the rear carrier portion 28, a sealing member 43 at its end 42 facing the front carrier portion 27 is positioned so that it is formed throughout the scope, respectively, held thereon. The sealing member 43 is preferably located at a front side of the rear carrier portion 28 and is held thereon. Because of the sealing element 43 which is configured in a circumferential manner, this lies both up to an outer surface 44 of the carpule 3 and up to an inner surface 45 of the front support portion 27, especially in the connecting section 31. This connection is preferably made with sealing effect throughout. the extent at both faces 44, 45, the sealing element 43 in the first coupling position of the two support housing parts 27, 28 being still located at a distance from the front wall 39 of the wall part 38 and the shoulder 41, respectively, formed on the front wall 39.
The front Carrier portion 27 includes a casing 46 which is approximately cylindrical in shape and provided in the region at the distal end 11 with the above-described opening 35, which is closed with the sealing plug 36. The garment 46 is formed throughout and thus is sealed. to the connection section 31. Only the passageways 37 are provided, through which, in the first coupling position of the two support housing parts 27, 28, a flow connection is formed to the front receiving space 29 on the front support housing part 27. provided one or more of the passageways 37 which, starting from the exterior of the front carrier portion 27, open into the front holding space 29. Thus, the front receiving space 29 of the front carrier housing 27 in the first coupling position is enclosed on one side with sealing effect. of the cladding 46, the sealing plug 36 located in the opening 35, the sealing element 43 as well as the carpule 3, which extends into the front take-up space 29 and permits a flow connection only at passage 37.
However, independently of this, it would also be possible not only to make the front take-up space 29 accessible through the sterilization passageways 37 but also to further provide an access to the rear take-up space 30. This could be realized by the fact that the sealing element 43, seen above the scope, is not completely up to the outer surface 44 of the carpule 3. The support of the carpule 3 on the rear carrier portion 28 can be provided via a few support spacers which are distributed over the scope and which are not shown further here. In addition, by means of the separate configuration of the carrier housing 2 in the front as well as the rear carrier housing 27, 28 a simple sterilization can be carried out by gas sterilization, and subsequently the sterile inner space can also be maintained over a longer period by a suitable sealing procedure for this. period of time.
In the second coupling position for the two support housing parts 27, 28, the sealing element 43 lies sealingly up to the front wall 39 of the wall part 38 and the shoulder 41, respectively, located thereon. To obtain a better circumferential seal, the wedge-shaped abutment 41 described above is provided which is axially pressed into the seal member 43 while adjacent thereto.
By means of the mutual displacement of the two carrier parts 27, 28 in the direction towards each other, the sealing element 43 is pushed past the passage 37, and there is a fully sealed front receiving space 29. In addition, the circumferential sealing element 43 can also serve as damping holder for the carpule 3 with the drug. 14, which is accommodated in the carrier housing 2. Thus, shocks and impact loads based on the external activating sheath 9 and to the carpule 3 with the medicament 14 can be attenuated or completely reduced or absorbed respectively.
A further damping device 86 appears in the context of a link of Figures 1 and 5. This is formed at the inner surface 45 of the carrier housing 2, in particular the front carrier housing 27, as a flange extending into the free cross-section or as a narrowing The positioning is made in axial direction in the storage position in the area at the section of the needle holder 23 and the guide element 24, respectively. In connection with a fall test, the carpule 3 and the needle holder 23 and / or the guide element 24 can support this, in this way a Inadvertent lateral movement of the carpule 3 towards the distal end 11 is stopped. The damping device 86 thus forms a mechanical resistance to an axial movement.
The access via the passage 37 in the first coupling position serves to sterilize the front take-up space 29 together with the needle device 6 disposed therein. Since the carpule 3 with the drug 14 stored therein during sterilization is located within the injection device 1, only a few sterilization options are possible. A sterilization with heat effect or with - 16 - DK 2010 00203 U4 radiation with electron beams should be avoided for these reasons so as not to adversely affect the drug 14. In the present embodiment, a gas sterilization is preferably selected by means of ethylene oxide via the passage 37 located in the connection section 31. This gas sterilization can also be referred to as ETO gas sterilization and is sufficiently known. Following the sterilization process, the two support housing portions 27, 28 are aligned with each other from their first coupling position to the second coupling position, whereby, as already described above, the circumferential sealing member 43 ensures complete closure of the front receiving space 29 relative to the external ambient conditions. Thereby, the entire needle assembly 6, as well as the carpal closure 26, is sterilized at the side facing the front recording space 29 and is in use until the use of the injection device 1 in this state, respectively.
In addition, it is possible that the injection device 1 prior to the sterilization by gas sterilization is completely enclosed by an enclosure not shown. In this connection, the enclosure can be selected from a high density, high density polyethylene (HDPE) paper fiber-like fiber textile fabric. The paper-fiber-like fiber-functional textile, for example, is marketed by the company DuPont under the brand name TYVEK and has the characteristic that the flow of ethylene oxide needed for the gas sterilization is enabled on the one hand, while the flow of germs and bacteria, respectively, is prevented in a safe way. Thus, for example, the injection device 1, which is in the first coupling position of the front and rear support members 27, 28, can be surrounded by the enclosure in a single or, however, multiple arrangement. Thereafter, the sterilization is carried out by means of the gas sterilization at a suitable location. After the sterilization, the two support housing portions 27, 28 are adjusted within a separate workflow to the second coupling position, thereby closing the front take-up space 29 with complete tightness relative to the external ambient conditions, as already described above in detail. If several injection devices 1 are stored in a tray or in a recording bowl, respectively, described in more detail below and covered by a cover in the recording bowl or surrounded by the enclosure, the tray may be at the respective wall portions facing the two ends 11, 12, have wall portions which are easily deformable and which allow the two carrier housing portions 27, 28 to be pushed together from the first coupling position to the second coupling position without damaging the tray in that connection. This is described in more detail in Figures 8 to 10.
The actuating sheath 9 is formed at its proximal end 12 in such a way that it serves to receive or connect the fuse sheath 18, respectively. For this purpose, a sheath wall 47 of the actuating sheath 9, which is predominantly formed in cylinder or tubular form, is in the region of its proximal end 12 has a reduced wall thickness and thus forms an uptake region on the outside of the hyster wall 47. A casing cover 49 engages at the side facing away from the longitudinal axis 13 over the uptake area 48 and is preferably formed so that it extends approximately in the same manner. plan as the outside of the casing wall 47.
In addition, at its proximal end 12 in the region of longitudinal axis 13, the actuating sheath 9 contains at least one actuating element 50 which is formed in wedge form. This actuating element 50 - 17 - DK 2010 00203 U4 may be designed so that it extends through the scope and at the side facing the drive unit 4 is provided with a cone surface 51 which is tapered in cone shape towards the side facing away from the drive unit 4. When the fuse cover 18 has been removed together with its fuse pin 19, it is thus possible, in connection with a relative displacement of the activation hyster 9 with respect to the carrier housing 2, to displace the ends of the holding arms 16, which are designed mirrored in relation to the cone surface 51 radially inward - that is, towards the longitudinal axis 13 - thereby obtaining a release of the holding disc 17. This release process is common in such injection devices 1 and thus belongs to the ordinary technical knowledge. Therefore, the detailed design of this activation and release mechanism for the first drive unit 4 is not further described.
As already described above, the sterilized storage position of the injection device 1 is shown in Figure 3, in which the anterior receptacle 29 as well as the needle 20, which later come into contact with the patient 10, respectively, for insertion and associated delivery of the drug 14 in the completely sterilized state is present. In addition, in the region at the proximal end 12 of the injection device 1, there is simplified shown an engagement device 52 which causes an engagement effect between the carrier housing 2, especially the rear carrier housing 28, and the activating housing 9.
Thus, the rear carrier member 28 is provided at its outer surface and in the region at the proximal end 12 with at least two engaging nozzles 53, 54 which are spaced apart in the direction of the longitudinal axis 13 and which cooperate with an engaging member 55 located on the activation sleeve 9, in two different length positions. The engaging element 55 formed on the activating sheath 9 is preferably a component of the casing wall 47 and may, for example, have a connection to an engaging arm which is resiliently formed or formed therefrom, respectively. In this connection, the first engaging nose 53 is positioned so that it is closer to the proximal end 12 than the second engaging nose 54. In this connection, the mutual distance between the two engaging noses 53, 54 preferably corresponds to the release path of the activating sheath 9 relative to to the carrier housing 2 necessary to be able to release at least the first drive unit 4 and thus activate the injection process. The two engaging noses 53, 54 define the relative positions of the carrier housing 2 relative to the activating sheath 9 on one side in the storage position and on the other in the injection position. In this connection, only a relative length adjustment of the activating sheath 9 relative to the carrier housing 2 from the storage position to the injection position is possible, while a length adjustment in a relative opposite direction is safely prevented.
The activation or release of the injection device 1 for the injection process from the storage position to the injection position takes place by holding the entire injection device 1 in the hand of a user at the activating sheath 9, after which the safety cover 18 is pulled by the proximal end 12 of the activating sheath 9. the subsequent injection process. Thereafter, the entire injection device 1 with its distal end 11 must be positioned at the site of the patient 10 where the drug 14 is to be delivered.
- 18 - DK 2010 00203 U4
Thereby, the distal end of the needle guard element 7 as well as optionally the sealing plug 36 located on the front support portion 27 of the opening 35 is supported. Due to the displacement of the activating sheath 9 towards the distal end 11 and thus towards the patient 10, due to the support of the support housing 2 on the body part of the patient 10, a relative displacement of the activating sheath 9 relative to the carrier housing 2. As already described above, the first drive unit 4, in particular the holding arms 16 held in engagement, is radially displaced by the actuating element 50 inwardly, thereby releasing the engagement with the holding disc 17.
The relative axial adjustment movement causes the resilient engagement member 55 to come out of engagement with the first engagement nose 53, slide over the second engagement nose 54 and then again be supported by this second engagement nose 54. In this way, the carrier housing 2 is held relative to the actuation sleeve 9. in a stationary position. This fixation is made in both axial directions, the first support being made between the holding arms 16 and the actuating element 50 and the second support between the second engaging nose 54 and the engaging element 55.
In addition, in the region of the distal end 11 as well as at its inner surface 56, the actuating sheath 9 has an abutment surface 57 which is preferably oriented perpendicular to the longitudinal axis 13. This abutment surface 57 may preferably be formed or positioned so that it extends through the inner circumference. of the actuating casing 9 and is preferably formed by a cylindrical or tubular recess in the casing wall 47.
Also, the needle guard element 7 is fixed under the bias of the second drive unit 8 relative to the carrier housing 2, in particular the front carrier housing portion 27 in the storage position. This relative and detachable fixation is most clearly seen in Figures 2 and 3 in the region of the distal end 11. The carrier housing 2 and the front carrier housing 27, respectively, are provided at their distal end 11 at its outer surface 58 with a preferably fully through impact member 59. On the needle protection element 7 corresponding to this is provided at least one arm member 60 which is shaped like a rocker and which in the direction of the longitudinal axis 13 has arms ends 61, 62 at a distance from one another. The arm 61, which is closest to the distal end 11, is supported in the storage position of the injection device 1 by the abutment element 59 described above on the front support portion 27 of the support housing 2. The second arm 62 extends into the recess described above on the activation sleeve 9 as well as in the direction towards the impact surface 57. Depending on the selected distance between the arm end 63 and the impact surface 57, the release time, which will be described later, for the needle protection element 7 and the second drive unit 8 which cooperate with it, can be varied. The second drive unit 8 with its propellant 40, shaped like a spring, is supported in the region at its end region facing the proximal end 12 on the inward wall portion 38. In addition, the second drive unit 8, particularly the drive means 40, is provided with its end region facing the distal end 11 supported on a front wall of the needle guard element 7 facing the proximal end 12. In this way, the drive means 40 for the other drive unit 8 is viewed in one radial direction - 19 - GB 2010 00203 U4 located between the carrier housing 2 and the activating sheath 9 and, on the other hand, seen in axial direction on the inward wall portion 38 of the carrier housing 2 as well as the front wall of the needle guard member 7. As a result of the support on the front wall of the needle guard member 7, the drive means 40 for the second drive unit 8, seen in the axial direction, located behind the needle guard element 7 and thus on the side facing the proximal end 12, respectively on the end section formed. Thereby, on the needle guard element 7, it produces a compressive force directed towards the distal end 11. This compressive force is transmitted from the needle guard member 7 via the arm member 60, respectively disposed thereon, to the impact member 59 located on the support housing 2, and is thus supported at this location.
As already described above, the entire needle assembly 6, in particular the needle 20 with its needle end 22 facing the carpal closure 26, is spaced at a distance therefrom in the storage position. In addition, the needle holder 23 is held axially displaceable in the guide member 24 and is respectively housed therein, the needle holder 23 in the storage position via at least one detachable holding member 63 being fixed relative to the guide member 24 in its position thereon. This is most evident in the diagram in Figure 1.
As can now be seen more clearly in Figures 2 and 3, an adjusting cam 64 extending beyond the needle holder 23 to the side facing away from the longitudinal axis 13 is assigned to the holding member 63 of the needle holder 23, respectively. In this section, the front support portion 27 of the support housing 2 has an internal free dimension or a cross-section, which is approximately cylindrical, and in this connection, the adjustment box 64 is located immediately adjacent or slightly adjacent to an inner wall 65 of the support housing portion 27, which are designed in holster form. If the carpule 3 together with the needle device 6 is now moved by means of the first drive unit 4 towards the distal end 11, the needle end 21 facing the distal end 11 first pierces the sealing plug 36 which is located in the opening 35 on the front support housing part. 27, and then goes directly into the surface section of patient 10 selected for delivery.
The activated and entrapped position of the cannula 20 in the patient 10 is most clearly seen in Figure 4. In this connection, the carpule 3 together with the needle device 6 has been displaced towards the distal end 11. Furthermore, in the region of the distal end 11 at the inner wall 65 on the front carrier part 27 forms a guide curve 66 which projects in the direction of the longitudinal axis 13, which is formed, for example, by a narrowing of the wall fin forming the front carrier part 27. However, a rib of an intermediate piece on the inner wall 65. The control curve 66, displaced in the direction of the longitudinal axis 13, with the associated reduction or narrowing of the cross-section, respectively, engages the displacement path of the needle device 6 with the adjustment box 64 and is displaced radially inwardly with the holding element 63. direction towards the longitudinal axis 13. As a result of this displacement, retaining elements come t 63 out of engagement with the guide member 24. Due to this release and the mechanical connection of the needle holder 23 up to the sealing plug 36 located at the distal end 11, a further relative displacement occurs between the needle holder 23 and the guide member 24. As a result, of this relative displacement, the needle end 22, facing the proximal end 12, pierces the carpal closure 26, thereby creating a flow connection between the inner space of the carpule 3 via the cannula 20 and to the insertion site of the patient 10. By means of the mechanical stop of the needle holder 23 on the sealing plug 36 and the end of the relative adjustment between the needle holder 23 and the guide element 24, the carpule 3 is also fixed stationary with respect to the carrier housing 2. The sealing plug 36 is in this connection at the end facing the needle holder 23 and the guide element respectively. 24, designed in such a way that it further takes over a tire muzzle function for the termination of the adjusting movement and the carpule 3, which is mostly made of glass, does not break due to the jerky adjustment movement and the associated collision at the distal end 11. Therefore, a preferably circumferential collar protrudes from the opening 35 in the direction of the front take-up space 29 and in this connection comes into contact with the needle device 6.
Due to the additional pressure or force effect, respectively, of the drive unit 4 towards the distal end 11, a carpule plug 68 located on a piston rod 67 is pressed into the inner compartment of the carpule 3, whereby the drug 14 is injected into the patient 10 via the at this time, needle cannulated 20.
In connection with the relative displacement of the activating sheath 9 relative to the carrier housing 2 and the associated release of the first drive unit 4, the second arm 62 on the arm member 60 facing the proximal end 12 comes into contact with the impact surface 57 which is formed on the inner surface 56 of the actuating sheath 9. The arm end 62 facing the proximal end 12 is pivoted in a radial direction towards the longitudinal axis 13. In a further consequence, the tilt-like bearing of the arm element 60 causes the first arm 61 on the arm element 60 facing the distal end 11 comes out of engagement with the impact member 59 due to a radial oscillation to the side facing away from the longitudinal axis 13. Thus, the support of the needle guard member 7 on the support housing 2, in particular the front support member 27, is lifted. and at the same time, the second drive unit 8 is activated. In this way, the needle guard element 7 is displaced when the injection process is completed and the injection device 1 is removed from the patient 10, immediately with the cooperating drive unit 8 from its inoperative position to the position where the needle end extending beyond the distal end of the carrier housing 2 is covered. It is advantageous when, in connection with the axial adjustment of the activating sheath 9 relative to the carrier housing 2, a simultaneous release of both the first and the second drive unit 4, 8 is made.
Figure 5 now shows the protected position of the needle 20 after the injection process and the removal from the injection site of the patient 10 within the needle guard member 7.
In addition, to prevent inadvertent resetting of the needle guard member 7 from the protective and covering position and to a new release position for the needle end 21, the needle guard member 7 is provided at its proximal end 12 with at least one locking member 69 which may be deformed elastically and may be formed as a resiliently deformable arm. The needle guard element 7 is displaced by the drive unit 8 during its relative displacement relative to the carrier housing 2 to the position where the needle device 6 is covered. A resetting of the needle guard element 7 towards the proximal end 12 is prevented by the support of the locking member 69 on the impact surface 57 formed on the inner surface 56 of the activating sheath 9. In this connection, the needle guard member 7 is adjusted by the second drive unit 8. over a predetermined setting path up to a mechanical stop. The securing element 69 protrudes into the clearance space before the impact surface 57. Furthermore, the securing element 69 may be located at a given distance in front of the impact surface 57, but 10 also in a direct connection thereto. The engagement position of the securing element 69 is supported, respectively, by the position of the needle guard element 7, where the needle device 6 is covered, further by means of an adjusting element 70 located on the support housing 2. The adjustment element 70 can be formed as a circumferential intermediate-like support housing or the support housing 2 respectively. 27, while adjusting element 70 during relative adjustment of the needle guard element 7 relative to the carrier housing 2, respectively, adjusts the securing element 69 in the radial direction to the side facing away from the longitudinal axis 13. By means of this mechanical fixation of the securing element 69 on the impact surface 57 as well as the radial bias caused by the adjusting member 70, a secure covering of the cannula 20 is secured by the needle guard member 7.
The relative adjusting movement of the needle guard member 7 in axial direction relative to the carrier housing 2 can be completed by a form-fitting stop between an engagement portion 71 located at the proximal end 12 and the adjusting member 70 located on the carrier housing 2 towards it. distal end 11. Thus, the needle guard element 7 is adjusted over a predetermined setting path towards the distal end 11, and in this connection the needle 20 for the needle device 6 in this position is completely covered. This is most evident in Figure 6.
Furthermore, it is further apparent from Figure 5 that the needle holder 23, by its side facing the carpal closure 26, comprises a sealing insert 85 which completely encloses the cannula 20 in a predetermined radial direction and protrudes in axial direction. direction. This sealing abutment is seen in an axial section designed in wedge shape, being tapered in the direction towards the carpal closure 26. When the carpal closure 26 is pierced by the cannula 20, leaks can occur in the immediate piercing area between the cannula 20 and the carpal closure 26. The density is provided in this case. by means of the sealing insert 85 in cooperation with the carpal closure 26, which is formed resiliently deformable, as the sealing insert 85 penetrates the material and, in addition, also presses it onto the cannula 20.
In Figure 7, the holding disc 17 of the securing device 5 is shown in a simplified view from above. Thus, at its center, the retaining disc 17 is provided with a breakthrough 72, which is preferably 40 circular, as well as additional recesses 73 joining it and extending outward in the radial direction. However, independently of this, it would also be possible to design the cross-section of the breakthrough 72 in square shape, especially square, as indicated by dotted lines. In this connection, the number of recesses 73 must be selected to correspond to the number of retaining arms 16 to be fixed in the storage position on the first drive unit 4. In the present embodiment, four retaining arms 16 are provided in a uniform distribution over the scope, and in this connection, the recesses 73 are provided in order to better position, guide and hold the holding arms 16 in the holding disc 17. Furthermore, the holding disc 17 is provided on its outside scope with additional segment-like stops 74. These stops 74 serve to connect the holding disc 17 to the rear carrier housing part. 28 on the support housing 2. This can be done, for example, in the form of a snap or engagement connection.
The delivery of the drug 14 stored in the carpule 3 can be carried out as follows. The two drive units 4, 8 are held securely in their biased position within the injection device 1, and in this connection the front receiving space 29 together with the whole needle device 6 is in the sterile state. If the injection is now to be delivered, the first drive unit 4 must first be released upon removal of the locking device 5, i.e. the locking cap 18 and the locking pin 19, for triggering and activating it, respectively. The user holds the entire injection device 1 by the activating sheath 9 and places it with its distal end 11 at the body part of the patient 10 where the medicine and the drug 14 respectively are to be delivered. Thereby, the support housing 2 is supported together with the needle protection element 7 placed thereon on the surface of the patient 10.
Due to the axial adjustment movement of the activating sheath 9 towards the distal end 11, the first drive unit 4 is respectively activated, whereby the carpule 3 together with the needle device 6 is automatically adjusted towards the distal end 11. During this axial adjustment movement, the needle holder 23 is released together. with the cannula 20 additionally from the fixed first position on the guide member 24, and the needle end 22 is inserted through the carpal closure 26. Prior to this piercing, the needle end 21 facing the distal end 11 has already penetrated the patient 10, the flow connection between the needle end 22 turns away from it, and the inner compartment of the carpule 3 immediately afterwards. Immediately thereafter or also at the same time as the axial adjustment of the activating sheath 9, the second drive unit 8 for movement of the needle guard element 7. Also, by means of the first drive unit 4, the drug 14 is delivered to patients 10. Upon completion of delivery, the entire injection device 1 is removed from the patient 10. By means of the already activated or triggered second drive unit 8, the needle guard element 7 is adjusted, while the injection device 1 is removed from the patient 10 until the cannula 20 is fully accommodated therein, respectively the engagement part 71 of the needle guard element 7 comes into contact with the adjustment element 70. At the same time, the complete axial adjustment of the needle guard member 7 to the covering position is prevented by means of the locking member 69 by a support on the impact surface 57 to be reset to a release position for the needle end 21.
Figures 8 to 10 show an example of a recording bowl 75 for receiving the injection device 1 or several of them, respectively, and in this connection again the same reference numerals or component names for similar components are used as in the previous two. Figures 1 to 7. To avoid unnecessary repetitions, reference is made to the detailed description of the preceding Figures 1 to 7, respectively.
The recording bowl 75 shown here may itself constitute an independent design according to the invention. In this connection, the purpose of the manufacture may consist in providing a recording bowl 75 which serves to receive preferably several consecutive injection devices 1, in which sterilization of the injection device 1 can also be performed, the subsequent closure process and the associated sterile closure of the sterilized compartment within the injection device 1 after sterilization may also be accomplished at the same time as the injection device 1 is in the recording bowl 75.
In this connection, the recording bowl 75 can also be referred to as a tray, which is formed, for example, of a deep-drawn film from a heat-deformable material such as, for example, from a plastic material. The injection device 1 shown in Figures 8 and 9 in the recording bowl 75 is shown without section and only in a simplified schematic view.
The receptacle bowl 75 is formed as a vessel and contains a bottom 76 as well as side walls 77 which rise therefrom. On the side of the sidewalls 77 facing away from the bottom 76, the receiving bowl 75 has a container rim 78. This is preferably configured so that it protrudes outwardly as a flange and serves to close with a cover 79 which in Figure 8 seen in a schematic simplified view. The cover 79 covers the entire interior space intended for receiving the injection device 1 and is enclosed by the receiving bowl 75 and can be selected from the above-described material or raw material, as described for encapsulation of the injection device 1. Since the paper-fiber-like fiber-functional textile of the thermally welded fibers allows for sealing or welding with the base material of the uptake wedge 75 by a suitable choice, the cover 79 in the region of the container rim 78 can thus be secured with sealing effect, being completely continuous. However, it would also be possible to keep the cover 79 on the container rim 78 on the receiving bowl 75 by means of a tight adhesive connection or the like. With regard to the material for the cover 79, it is essential that it is possible to carry out the gas sterilization and the associated sterilization through the cover 79, without subsequently germs or bacteria being released through the cover 79. Thus, the material for the recording bowl 75 must also be selected for such This means that a complete germ or bacterial seal is also made here.
Depending on the outside dimensions of the activating sheath 9, holding elements 80 are formed here in the region of the bottom 76 in successive rows in the region of the bottom 76. These serve to squeeze up the injection device 1 and thus define the position of the injection device 1 within the recording bowl 75. However, it would also be possible to dispense with the squeezing effect of the holding members 80 and omit them completely. Independently of this, it could also be conceived that instead of the squeezing effect of the holding members 80, only separating plates are placed between the injection devices 1 which are placed in the recording bowl 75, so as to obtain at least a rough positioning respectively. mutual position orientation of the injection devices 1 in front of each other.
Furthermore, it is seen by linking Figures 8 and 10 in the region of the distal and proximal ends 11, 12 of the injection device 1, that in each case the opposite side walls 77 are respectively placed deformable wall sections 81. in this connection, wall sections 81 are each assigned to the distal end 11 and proximal end 12, respectively, adjacent to them. In the coupling position of the two support housing portions 27 and 28, by which an access through the passage 37 to the front take-up space 29 is possible, support portion 82 protrudes on the deformable wall portions 81, which are preferably oriented perpendicular to the bottom 76, up to the distal respectively. proximal ends 11, 12. By correspondingly selecting the dimension, a sufficient axial orientation of the individual injection devices 1 within the recording bowl 75 is obtained here. However, independently of this, it would also be possible to dispense with the deformable wall sections 81 and design the support sections or support sections. 82 of the sidewalls 77 themselves in a virtually flat design. In this connection, a sufficient opportunity for a deforming movement of the sidewalls 77 to effect the above-described adjusting movement of the two support housing parts 27, 28 relative to each other must be ensured.
In connection with this support section 82, the deformable wall section 81 comprises deformation section 83 which is enlarged outwardly in step shape and each proceeds in semi-circular shape 83. The deformation sections 83 located one after the other in step shape join in connection with the support section 82 in direction. The beginning of the deformation sections 83 extending in semicircular form is in this connection chosen approximately at the height of the longitudinal axis 13 of the injection device 1 at the position enclosed in the recording bowl 75 as well as preferably parallel to the bottom 76 and the container rim 78, respectively. stair-shaped and step-shaped positions one after the other, a very high deformation path is obtained for the wall sections 81, without these deformation paths being associated with damage to the recording bowl 75. This is important because it may otherwise occur that germs or bacteria, respectively, penetrate it otherwise completely. permanently enclosed recording space in the recording bowl 75.
In Figure 8, it is seen simplified by arrows pointing towards each other, characterized by "F", that the above-described adjusting movement between the two support housing parts 27, 28 can be effected by providing the compressive force drawn.
Furthermore, it is seen in Figure 8 in simplified view that the injection device 1 may be provided with a marking 84 which can be seen in the first coupling position of the two support housing parts 27, 28 but can no longer be identified or seen in the second coupling position which is shown in Figure 9. However, independently of this, other possibilities could also be envisaged to show the regulatory closure of the front recording space 29 so that it can be optically identified without the need for complicated monitoring devices. This could be achieved, for example, by a simple red / green marking in a control window in the activating sheath 9, for example, the red marking may indicate, for example, the first coupling position and the green marking, the second, sterile coupling position between the two carrier housings 27 28. This can be achieved at the relative position of the front support member 27 relative to the activating sheath 9, the marking shown being dependent on the position in question.
By means of the further configuration or use of the recording bowl 75, it is possible to prepare the injection device 1 in a pre-mounted state for the sterilization and then, for example, to carry it out at a further operating site intended for this purpose and, after completion of sterilization, to carry out the adjustment of the two carrier parts. 27, 28 to the second coupling position. Also, due to the complete enclosing of the injection device 1 within the receiving bowl 75 and the associated cover 79, sterile transport pathways may not be planned after sterilization and even a complete closure in the second coupling position.
After the sterilization performed, all the structural elements of the injection device 1 available for the ETO gas sterilization are sterilized or are in such condition, respectively. The subsequent alignment of the two support housing portions 27, 28 to each other and the associated fully sealed closure of the front take-up space 29 can then be accomplished with a mechanical device not shown herein. The proper closure may be effected by means of the optical or sensory control of the marker 84 described above.
When the two carrier housing portions 27, 28 are pushed together, the cover 79 can be removed from the recording bowl 75 and the sterilized injection devices 1 are removed from the recording bowl 75 and optionally further packaged in individual packages.
Figures 11 and 12 show a further and possibly self-contained embodiment of the needle device 6, in particular for the needle holder 23 and the guide element 24, on the injection device 1, and in this connection again the same reference numerals or component names for similar parts are used as in 1 to 7. In order to avoid unnecessary repetitions, the detailed description is referred to the previous figures 1 to 7, respectively.
As already described above, the needle holder 23 and the cannula 20 received or held therein, respectively, are mounted in axially longitudinally displaceable relation to the guide member 24 therein. Also shown in Figure 11 is the support of the retaining element 63 on the guide member 24. On the holding member 63 is placed the above-described adjusting cam 64, which in connection with the axial adjustment of the carpule 3 together with the guiding member 24 as well as the needle holder 23, release the fixing, whereby the insertion of the needle end 22 in the carpal closure 26 takes place.
The guide member 24 is formed in the exemplary embodiment shown here by two guide members 87, 88 which can be assembled in half-bowl form to the tubular guide member 24.
- 26 - DK 2010 00203 U4
By means of the elevated position of the guide member 87, shown in FIG. In addition, the needle holder 23 is preferably provided with diametrically opposed guide guides 89 which engage a guide slot 90 in the guide portion 87 and / or 88.
In the mounted position of the stool member 24 shown in FIG. 11, the needle holder 23 is held in a fixation in both axial directions relative to the guide member 24. The guide shoulder or guides 89, in cooperation with the guide slot 90, restrict the adjusting movement of the needle head 23 towards the distal end 11. The retaining element (s) 63, on the other hand, prevents axial adjustment of the needle holder 23 towards the proximal end 12 until its release due to the interaction between the adjustment box 64 and the guide basket 66 on the support housing 2. The relative axial adjustment movement of the needle holder 23 towards the proximal end 12 and the associated piercing of the needle end 22 through the carpal closure 26 may be restricted through the selected length extension of the stool slot 90.
The two guide members 87, 88, which in this case are formed as half-bowl parts, are prevented in the assembled state by their connection to the inner surface 45 of the support housing 2, in particular the front support housing part 27, from falling apart. This provides a simple mounting with a strong connection. In addition, there is also the possibility of a mutual fixation of the two guide members 87, 88 by means of pins and tap recordings which are displaced relative to each other.
This axial guide has the advantage that there is also an axial insertion movement of the cannula 20 relative to the longitudinal axis 13 of the tissue of the patient 10 or the user.
In Figure 13, the interaction already described above between the control curve 66 on the carrier housing 2, in the present embodiment, the front carrier part 27, and the adjustment box 64 located on the holding element 63, are shown in an enlarged view.
This results in a radial displacement and the associated release of the fixation between the holding element 63 and the guide element 24. Depending on the position of the control curve 66 seen in the axial direction, the release for the insertion movement of the nil end 22 in the carpule plug 26 can also be determined. The earlier this release occurs, the faster the cannula 20 has a flow connection to the inner compartment of the carpule 3 which receives the drug 14.
In Figures 14 and 15, the injection device 1 is shown according to the diagram of Figures 1 to 7 as well as 11 to 13, and in this connection again the same reference numerals and component names for similar parts are used as in the previous figures. To avoid unnecessary repetitions, reference is made to the detailed description of the preceding Figures 1 to 13, respectively.
- 27 - DK 2010 00203 U4
The individual structural members forming the injection device 1 are sized in such a way that they can be assembled or pre-assembled into structural groups or structural units 91, 92, respectively. Within a subsequent further mounting step, the two structural units 91, 92 are thus joined with the remaining structural elements, thus as this is shown in Figure 1.
Thus, a first structural unit 91 in the region at the distal end 11 of the injection device 1 comprises the front support member 27, the sealing plug 36 as well as the needle guard member 7 which can be adjusted with the second drive unit 8.
The needle guard element 7 is, for its part, supported by the impact member 59 on the front support member 27 via the holding member 60 described above and held in engagement. The second drive unit 8, which in this case is formed of a compression spring-shaped spring, is supported on one side by the connecting section 31, which has indentations in step shape, on the front support part 27 and on the other side on a front side. on the needle guard member 7 facing the proximal end 12. By means of the prestressed drive unit 8, the axial adjustment of the needle guard member 7, after the previously described release of the arm member 60, can be made to the position where the needle or needle 20, respectively, is covered.
The second structural unit 92 in the region at the proximal end 12 of the injection device 1 comprises, for its part, the rear support housing portion 28, the first drive unit 4 accommodated therein, the carpule 3 with its carpule plug 26, the needle device 6, the sealing element 43, the piston rod 67 with the carpule plug 68 as well as the holding arms 16 which can be held in position by the holding disk 17. In order to prevent an unintended release of the first drive unit 4 caused by the holding arms 16 coming out of engagement with the holding disk 17, it is seen here in Figure 15 in a simplified view that the holding arms 16 are held in a radial direction via a securing element 93 located in the region of the longitudinal axis 13 relative to the side facing away from the longitudinal axis 13. The securing element 93 is preferably formed in pin shape and remains on the structural unit 92 until the final assembly with the structural unit 91 as well as the activating sheath 11 and the securing device 5 has been made.
Thereby, a high degree of prefabrication can be achieved, depending on the desired drug, also the carpule 3 with the needle device 6 placed thereon via the carpule plug 68 can be connected to the piston rod 67. The mounting of the carpule 3 on the piston rod 67 can then be carried out depending on the storage capacity of the drug 14.
Thereby, a simple method can be provided for the assembly of the injection device 1, in which method the construction units 91, 92 described above are first constructed together with all their details and thus form a semi-finished or pre-product respectively. Thus, external production of the individual structural elements can also be made, and the pre-assembled structural units 91, 92 can, for example, be manufactured by different manufacturers in a separate process and assembled. When the first structural unit 91 in conjunction with the assembly is joined together with the second structural unit 92 in the area of the connection section 31 according to the position shown in Figure 1, this structural group consisting of the two structural units 91 92 is then inserted into the activating sheath 9. Already before or even afterwards, the securing element 93, which is preferably configured in pin form, must be removed in the region of the holding arms 16 and replaced by the locking device 5, which is formed in the casing shape, with the securing pin 19. The above-described sterilization is carried out in the inner compartment of the carrier housing 2, especially in the area of the needle device 6.
As already shown above in connection with Figures 1 to 6, the piston rod 67 is provided with a radially circumferential groove 94 which, in the pre-mounted position of the piston rod 67 at the carpule 3, is respectively located at the end of the carpule 3 facing the proximal end 12. This reduction of the outside dimension, in particular of the diameter of the piston rod 67, serves to avoid damage to the carpule 3, which is mostly or preferably made of glass, at its proximal end throughout the storage time. for the injection device in connection with any distortion of the carpule 3 relative to the piston rod 67. In this way, the piston rod 67 is connected to the carpule plug 68. This can preferably be achieved by means of a threading device. In the immediate abutment area of the piston rod 67 at the carpule plug, it is provided with a shoulder 95, which is preferably formed in flange form. This abutment 95 serves for mutual axial fixation between the piston rod 67 and the carpule plug 68. The clearance space of the piston rod 67, which is designed as a recess 94, thus protects against damage during transport or in a situation where the injection device 1 is accidentally lost. A further attenuating support of the carpule 3 can be obtained by means of the sealing element 43 on the rear support member 28, as already described above.
The exemplary embodiments show possible embodiments of the injection device 1, and it should be noted in this connection that the production is not limited to the particular embodiments thereof, but that, on the contrary, various combinations of the individual embodiments are possible, and that this possibility of variation on the basis of the technical information of a specific production is within the competence of a professional working in this technical field. Thus, all conceivable embodiments that may arise from combinations of individual details of the embodiment and described embodiment are also included in the scope of protection.
Finally, it should be noted that the injection device 1 and its constituents, respectively, for a better understanding of its structure are partly shown in a non-scaled image and / or enlarged and / or reduced.
The purpose underlying the self-generating solutions is set out in the description.
DK 2010 00203 U4 - 29-
Above all, the individual embodiments shown in Figures 1 to 6 may be; 7; 8 to 10; 11, 12; 13; 14; 15, each forming the object of independent solutions according to the invention. The related objects and solutions according to the invention appear from the detailed descriptions of these figures.
- 30 -DK 2010 00203 U4
Reference designation list 1 Injection device 2 Carrier housing 51 Cone face 3 Carpule 52 Interlocking device 4 Drive unit 53 Interlocking nose 5 Securing device 54 Interlocking nose 55 Interlocking element 6 Needle device 7 Needle protection element 56 Internal surface 8 Drive unit 58 Armature surface 59 Abutment surface 59 Envelopment surface 9 Activation surface 9 13 Lashing axle 62 Arming 14 Medication 63 Holding element 15 Fuel 64 Adjusting knob 65 Internal wall 16 Holding arm 17 Holding disc 66 Steering curve 18 Fuse cover 67 Piston rod 19 Fuse pin 68 Carpule plug 20 Needle 69 Fuse element 70 Adjusting element 21 Retaining 22 Needle retaining 73 Retaining part 72 Retaining part 23 Carp end 74 Staff 75 Recording bowl 26 Carpal closure 27 Carrying part 76 Bottom 28 Carrying part 77 Side wall 29 Recording space 78 Container edge 30 Recording space 79 On cover 80 Holding element 31 Connection section 32 Coupling device 33 Locking element 34 Locking element 35 Opening 36 Sealing plug 37 Throughout 38 Wall part 39 Front wall 40 Fuel 41 Employee 42 End 43 Sealing element 44 Exterior surface 45 Inner surface 46 Cladding 47 Sheath wall 50 Recording area 49 00203 U4 Wall section Support section Deformation section Marking Sealing device Damping device Guiding part Guiding part Guiding member Guiding slit Design unit Construction unit Securing element Deepening groove

权利要求:
Claims (28)
[1]
Injection device (1), in particular auto-injector, designed to be adjusted from a storage position to an injection position, with a carrier housing (2) having a distal end (11) facing a patient (10). and a proximal end (12) facing away from it between which the end longitudinal axis (13) extends, an actuating sleeve (9) at least partially enclosing the support housing (2), the distal end (11) of the support housing (2) protrudes past the actuating casing (9) and wherein the carrier housing (2) is surrounded by the actuating casing (9) over the greater part of its longitudinal extension between the distal and the proximal end (11, 12). can be adjusted relative to the bearing housing (2) in the axial direction, a carpule (3) with a medicament (14) contained therein and to be delivered in connection with the injection process, the carpule (3) being received in the carrier housing (2). ), a first drive (4) having an effective connection ten In the carpule (3) as well as to the actuating sheath (9) and can be triggered by the actuating sheath (9), a securing device (5) which fixes the first drive unit (4) in its position relative to the carrier housing (2) until actuated by means of the injection sheath (9) for the injection process, a needle device (6) located in front of the carpule (3) in the storage position of the injection device (1) in the section at the distal end (11), and both needle ends (21, 22) disposed on a cannula (20) within the carrier housing (2), a needle guard element (7) that can be displaced from an inoperative position to a position where the needle end (21) protruding beyond the distal end (11) ) of the carrier housing (2) is covered, a second triggerable drive unit (8) which displaces the needle guard element (7) from the inoperative position to the covering position, characterized in that the needle guard element (7) with the drive unit ( 8), the r cooperates with the actuating sleeve, seen in an axial section, in the radial direction between the carrier housing (2) and the actuating housing (9), and in that the carrier housing (2) comprises a front and a rear carrier housing (27, 28) each with a front and a rear take-up compartment (29, 30) and the two carrier housing parts (27, 28) in a connecting section (31) can be coupled to each other via a coupling device (32) in the direction of the longitudinal axis (13) in two different length positions in a first and in a second coupling position.
[2]
Injection device according to claim 1, characterized in that the front support housing part (27) in the connecting section (31) of the coupling device (32) engages the upper support housing part (28).
[3]
Injection device according to one of claims 1 or 2, characterized in that the carrier housing parts (27, 28) in the first coupling position in the coupling device (32) have a greater length extension relative to the second coupling position.
[4]
Injection device according to one of claims 1 to 3, characterized in that the coupling device (32) at the two support housing parts (27, 28) comprises in each case cooperating locking elements (33, 34) and are designed in such a way in each case, the two support housing parts (27, 28) are fixed in a different direction in a direction of movement which, in the direction of the longitudinal axis (13), is opposite and facing away from each other.
[5]
Injection device according to one of claims 1 to 4, characterized in that the distal end (11) of the front carrier part (27) is provided with an opening (35) which allows a passage of the needle end (21) in the needle device (6). ) and in which a plug-in sealing plug (36) is placed in a sealing position.
[6]
Injection device according to one of Claims 1 to 5, characterized in that the front carrier part (27) has a passage (37) in the connecting section (31).
[7]
Injection device according to one of claims 1 to 6, characterized in that the front bearing housing part (27) of the connecting section (31) is at a front wall (39) facing the rear support housing part (28) and inwards towards the longitudinal axis ( 13), is provided with a shoulder (41) which, in axial section, is designed in wedge shape and is designed so that it is continuous over the scope.
[8]
An injection device according to one of claims 1 to 7, characterized in that a sealing element (43) is provided on the rear carrier part (28) at an end (42) facing the front carrier part (27). designed so that it is consistently above the scope.
[9]
Injection device according to claim 8, characterized in that the sealing element (43) lies sealingly up to an outer surface (44) of the carpule (3) and an inner surface (45) of the front carrier part (27) and in the first coupling position. for the two support housing parts (27, 28) are located at a distance from the front wall (39) and the shoulder (41) formed on the front wall (39), respectively. - 34 - DK 2010 00203 U4
[10]
Injection device according to one of claims 1 to 9, characterized in that the passage (37) located in the front carrier part, in the first coupling position of the two carrier parts (27, 28), opens into the front receiving space (29). on the front bearing body portion (27) and having a flow connection thereto. 5
[11]
Injection device according to one of claims 8 or 9, characterized in that the sealing element (43) in the second coupling position for the two support housing parts (27, 28) seals up to the inward front wall (39) and the shoulder (41) respectively. positioned thereon and that access to the front recording space (29) via the passageway (37) is further interrupted. 10
[12]
Injection device according to one of claims 1 to 11, characterized in that the rear carrier part (28) contains at its outer surface and in the region at its proximal end (12) two engagement nozzles (53, 54) at a distance from one another in the longitudinal axis ( 13) direction cooperating with an engaging element (55) located on the activating sheath (9) in such a way that the engaging noses (53, 54) define the relative mutual positions between the carrier housing (2) and the activating sheath (9). on the one hand in the storage position and on the other hand in the injection rack, and that only a relative length adjustment of the activation housing (9) relative to the carrier housing (2) is possible from the storage position and to the injection position, while a relative length adjustment in the opposite direction. however, is prevented. 20
[13]
Injection device according to one of the preceding claims, characterized in that the actuating sheath (9) is provided in the region at the distal end (11) as well as at its inner surface (56) with an abutment surface (57) which is preferably oriented perpendicularly on the longitudinal axis (13). '25
[14]
Injection device according to one of the preceding claims, characterized in that on the needle guard element (7) there is placed an arm element (60) which is shaped like a rocker, with arm ends (61, 62) which are spaced apart in the longitudinal axis of the needle. (13) direction, in which the arm member (60) in the storage position of the injection device (1) with its arm (61) facing the distal end (11) of the support housing (2) is supported by a stop member (59) which is located on the support housing (2) on its outer surface (58).
[15]
Injection device according to one of the preceding claims, characterized in that the needle protection element (7) at its proximal end (12) further comprises a securing element 35 (69) which is designed to be resiliently deformed and which at the position of the needle guard element (7), where the needle device (6) is covered, is supported by the abutment surface (57) formed on the inner surface (56) of the activating sheath (9).
[16]
Injection device according to one of the preceding claims, characterized in that the securing element (69) at the position of the needle protection element (7), where the needle device (6) is covered, is additionally supported in a radial direction on an adjusting element (70) which is located on the bearing housing (2). - 35 - DK 2010 00203 U4
[17]
Injection device according to claim 17, characterized in that the adjusting element (70) is designed to be continuous, and that the needle guard element (7) at the position of the needle guard element (7), with the needle device (6) is covered, with its proximal end (12) is further supported by the adjusting element (70) in the direction towards the distal end (11) of the support housing (2).
[18]
An injection device according to one of the preceding claims, characterized in that the needle device (6) comprises a needle (20), a needle holder (23) disposed thereon, as well as a guide element (24) which receives the needle holder (23). ), the guide member (24) being coupled to a carpal end (25) facing the distal end (11) of the injection device (1) and the needle end (22) of the cannula (20) facing the carpal end (25) , in the storage position is located in front of a carpal closure (26) which can be pierced by the needle end (22).
[19]
Injection device according to claim 18, characterized in that the needle holder (23) is held axially displaceable in the guide element (24) and in the storage position of the needle holder (23) via at least one detachable holding element (63) fixed relative to the guide element (24). ) in his position on this.
[20]
Injection device according to claim 19, characterized in that on the holding element (63) is arranged an adjusting cam (64) which projects beyond the holding element (63) in a radial direction towards the side facing away from the longitudinal axis (13).
[21]
Injection device according to one of the preceding claims, characterized in that a piston rod (67) for the first drive unit (4) contains a radially circumferential clearance which is formed as a depression (94) and which in the storage position of the injection device (1) ) is located in the region at the proximal end of the carpule (3).
[22]
An injection device according to one of the preceding claims, characterized in that the first drive unit (4) is released after the release of the locking device (5) located at the proximal end (12) and in connection with a subsequent axial adjustment of the actuating sheath. (9) relative to the bearing housing (2) and the first drive unit (4) displacing the carpule (3) together with the needle device (6) in the direction of the distal end (11).
[23]
Injection device according to one of the preceding claims, characterized in that the carrier housing (2), in particular the front carrier housing part (27), is provided at its distal end (11) with a control curve (66) projecting in the direction of the longitudinal axis. (13), which, after adjusting a preset path for the carpule (3), can be engaged with the adjusting cam (64) located on the retaining member (63) and in doing so adjusting the detachable retaining member (63) on the needle holder (23) to a release position. - 36 - DK 2010 00203 U4
[24]
Injection device according to one of the preceding claims, characterized in that the needle holder (23) in the injection position is supported at the distal end (11) of the carrier housing (2) and that the needle holder (23) together with the needle (20) is relatively proportional. the guide member (24) is displaced so much in the direction of the carpal end (25) which is closed with the carpal closure (26) which can be pierced that the needle end (22) on the cannula (20) facing the carpule (3) has a flow connection to the drug (14) contained in the carpule (3).
[25]
The injection device according to one of the preceding claims, characterized in that also the second drive unit (8) which cooperates with the needle guard element (7) is released with the axial adjustment of the actuating sheath (9) relative to the carrier housing (2), and in that connection, the needle guard element (7) is displaced from its inoperative position to a position where the needle end (21) which protrudes beyond the distal end (11) of the carrier housing (2) is covered.
[26]
Injection device according to one of the preceding claims, characterized in that with the axial adjustment of the actuating sheath (9) relative to the carrier housing (2) a simultaneous release of both the first and the second drive unit (4, 8) takes place. .
[27]
Injection device according to one of the preceding claims, characterized in that a propellant (40) in the second drive unit (8) with its end region facing the distal end (11) is supported on an end section of the needle protection element (7). facing the proximal end (12).
[28]
Injection device according to one of the preceding claims, characterized in that the securing device (5) comprises a retaining disc (17) which is provided at its center with a breakthrough (72) and furthermore recesses (73) joining it and extending outward in the radial direction, to the holding arms (16) to be fixed by the holding disc (17) in the storage position, in the second drive unit (8). DK 2010 00203 U4 H ,, Fig »1 1/13 pr *

DK 2010 00203 U4 2/13 Fig.2

DK 2010 00203 U4

P1 # s S DK 2010 00203 U4 4/13

DK 2010 00203 U4

"Oh, yeah. £ "3: DK 2010 00203 U4 ./ j! Dl id i i ids dsdi '' '! A N i MNg' <ii f Pk ^ loi J i h>, Ks1 M J

£ 1WJ DK 2010 00203 U4

DK 2010 00203 U4



2010 ° 0203 U4 DK 2010 00203 U4

DK 2010 00203 U4 11 / · 13

DK 2010 00203 U4

DK 2010 00203 U4

类似技术:

---

公开号 | 公开日 | 专利标题

---

DK201000203U1|2010-11-12|injection device

---

US10369271B2|2019-08-06|Needle changing apparatus

---

JP5680852B2|2015-03-04|Device for drug delivery

---

US20140224688A1|2014-08-14|Package for a medicament delivery device

---

US20080183140A1|2008-07-31|Syringe cartridge system

---

JP2014534021A|2014-12-18|Needle hub and disposal device for disposable needle assemblies

同族专利:

---

公开号 | 公开日

---

RU2505322C2|2014-01-27|

---

EP2331177B1|2013-12-18|

---

CA2728099C|2018-01-16|

---

AU2009260162A1|2009-12-23|

---

WO2009152542A1|2009-12-23|

---

EP2331177A1|2011-06-15|

---

CN102112168A|2011-06-29|

---

CN102112168B|2013-05-01|

---

AU2009260162B2|2014-01-23|

---

MX2010013979A|2011-05-30|

---

BRPI0915310A2|2019-09-24|

---

PL2331177T3|2014-07-31|

---

CA2728099A1|2009-12-23|

---

KR20110043602A|2011-04-27|

---

US20110125100A1|2011-05-26|

---

AT506690B1|2009-11-15|

---

JP2011524212A|2011-09-01|

---

ZA201100377B|2012-04-25|

---

HK1158994A1|2012-07-27|

---

RU2011101457A|2012-08-27|

---

US8647306B2|2014-02-11|

---

JP5497753B2|2014-05-21|

---

ES2452542T3|2014-04-01|

---

AT506690A4|2009-11-15|

引用文献:

---

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

---

---

US4031893A|1976-05-14|1977-06-28|Survival Technology, Inc.|Hypodermic injection device having means for varying the medicament capacity thereof|

---

US4850968A|1987-07-27|1989-07-25|Ar.Ma.S.R.L.|Self-blocking hypodermic syringe for once-only use, comprising a needle protection cap|

---

GB9200219D0|1992-01-07|1992-02-26|Medimech Int Ltd|Automatic injectors|

---

US5658259A|1995-10-19|1997-08-19|Meridian Medical Technologies, Inc.|Dental cartridge assembly auto-injector with protective needle cover|

---

DE29801168U1|1998-01-24|1999-08-12|Medico Dev Investment Co|Injection device|

---

RU2181057C2|1998-05-05|2002-04-10|Государственный научно-исследовательский испытательный институт военной медицины|Automated injector device|

---

DE19925904C1|1999-06-07|2001-02-01|Disetronic Licensing Ag|Unit for subcutaneous application of an injectable product comprises a system which indicates whether the protection sleeve of the injection needle is in its fully retracted position|

---

US6767336B1|2003-01-09|2004-07-27|Sheldon Kaplan|Automatic injector|

---

AT7347U1|2003-08-29|2005-02-25|Pharma Consult Ges M B H & Co|DEVICE FOR THE AUTOMATIC INJECTION OF INJECTION LIQUIDS|

---

DE10348185A1|2003-10-16|2005-05-19|Tecpharma Licensing Ag|Injection device for administering fluid product e.g. insulin, comprising injection needle and needle cover arranged on holder or on casing so that it can shift and generally surrounds injection needle in advanced position|

---

DE10351599A1|2003-11-05|2005-06-16|Tecpharma Licensing Ag|Auto-injection device|

---

EP3804789A1|2004-04-29|2021-04-14|AbbVie Inc.|Autoinjector with extendable needle protector shroud|

---

US20050278012A1|2004-06-10|2005-12-15|Design & Performance - Cyprus Limited|Protected stent delivery system and packaging|

---

JP5356817B2|2005-09-01|2013-12-04|オウエンマンフォードリミティド|Needle shroud assembly|US6663602B2|2000-06-16|2003-12-16|Novo Nordisk A/S|Injection device|

---

EP1476210B1|2002-02-11|2008-09-24|Antares Pharma, Inc.|Intradermal injector|

---

CN100571804C|2004-10-21|2009-12-23|诺和诺德公司|The downward toggle mechanism that is used for wind-up pen|

---

KR20070117543A|2005-01-24|2007-12-12|앤태어스 파머, 인코퍼레이티드|Prefilled needle assisted jet injector|

---

WO2007131025A1|2006-05-03|2007-11-15|Antares Pharma, Inc.|Injector with adjustable dosing|

---

WO2007131013A1|2006-05-03|2007-11-15|Antares Pharma, Inc.|Two-stage reconstituting injector|

---

US8814834B2|2008-03-10|2014-08-26|Antares Pharma, Inc.|Injector safety device|

---

ES2738539T3|2008-08-05|2020-01-23|Antares Pharma Inc|Multi dose injector|

---

WO2010108116A1|2009-03-20|2010-09-23|Antares Pharma, Inc.|Hazardous agent injection system|

---

EP2665503A4|2011-01-11|2017-11-29|SHL Group AB|Medicament delivery device|

---

US8939943B2|2011-01-26|2015-01-27|Kaleo, Inc.|Medicament delivery device for administration of opioid antagonists including formulations for naloxone|

---

US9084849B2|2011-01-26|2015-07-21|Kaleo, Inc.|Medicament delivery devices for administration of a medicament within a prefilled syringe|

---

CN102614564B|2011-01-31|2014-07-16|中国人民解放军军事医学科学院毒物药物研究所|Automatic emergency syringe|

---

US8627816B2|2011-02-28|2014-01-14|Intelliject, Inc.|Medicament delivery device for administration of opioid antagonists including formulations for naloxone|

---

BR112013025628B1|2011-04-05|2021-01-12|Shl Medical Ag|medicament delivery device comprising a locking mechanism with a lever|

---

US8496619B2|2011-07-15|2013-07-30|Antares Pharma, Inc.|Injection device with cammed ram assembly|

---

US9220660B2|2011-07-15|2015-12-29|Antares Pharma, Inc.|Liquid-transfer adapter beveled spike|

---

EP2797650A2|2011-12-29|2014-11-05|Novo Nordisk A/S|Torsion-spring based wind-up autoinjector pen with dial-up/dial-down dosing mechanism|

---

US9486583B2|2012-03-06|2016-11-08|Antares Pharma, Inc.|Prefilled syringe with breakaway force feature|

---

AU2013203784A1|2012-04-06|2013-10-24|Kaushik J. Dave|Needle assisted jet injection administration of testosterone compositions|

---

WO2013169800A1|2012-05-07|2013-11-14|Antares Pharma, Inc.|Injection device with cammed ram assembly|

---

US9586007B2|2012-06-29|2017-03-07|Novo Nordisk A/S|Shield lock for spring driven injection device|

---

CN113730703A|2012-10-17|2021-12-03|椭元医疗技术有限公司|Automatic drug delivery device|

---

JP6647043B2|2012-10-25|2020-02-14|ノボ・ノルデイスク・エー／エス|Pre-filled disposable injection device|

---

WO2014080020A1|2012-11-23|2014-05-30|New Injection Systems Ltd|Auto-injector assembly|

---

JP2016504101A|2012-12-19|2016-02-12|ノボ・ノルデイスク・エー／エス|Needle device|

---

CA2900672C|2013-02-11|2018-03-27|Antares Pharma, Inc.|Needle assisted jet injection device having reduced trigger force|

---

PT2774640E|2013-03-08|2015-02-09|Teva Pharma|Re-useable injector device for syringe|

---

US8591463B1|2013-03-08|2013-11-26|Teva Pharmaceutical Industries Ltd.|Re-useable injector device for syringe|

---

US8652100B1|2013-03-08|2014-02-18|Teva Pharmaceutical Industries, Ltd.|Re-useable injector device for syringe|

---

ES2742046T3|2013-03-11|2020-02-12|Antares Pharma Inc|Dose injector with pinion system|

---

WO2014165136A1|2013-03-12|2014-10-09|Antares Pharma, Inc.|Constant volume prefilled syringes and kits thereof|

---

EP2777684A1|2013-03-14|2014-09-17|Sanofi-Aventis Deutschland GmbH|Medicament container carrier and adapter|

---

AT514484B1|2013-06-24|2015-05-15|Pharma Consult Gmbh|Activator for an auto-injector|

---

WO2014205604A1|2013-06-28|2014-12-31|群康生技股份有限公司|Syringe|

---

USD745664S1|2013-11-25|2015-12-15|Teva Pharmaceutical Industries, Ltd.|Injector device for a syringe|

---

EP2881131B1|2013-12-05|2019-04-24|TecPharma Licensing AG|Drive and metering device for an injection device with a pre-tensioned drive spring|

---

US10881796B2|2014-03-12|2021-01-05|Min Wei|Automatic medication injection device|

---

CN106456889B|2014-06-27|2020-03-17|诺和诺德股份有限公司|Automatic injector with needle shield lock|

---

US9517307B2|2014-07-18|2016-12-13|Kaleo, Inc.|Devices and methods for delivering opioid antagonists including formulations for naloxone|

---

US9415176B1|2015-01-22|2016-08-16|West Pharmaceutical Services, Inc.|Autoinjector having an end-of-dose visual indicator|

---

EP3247426B1|2015-01-22|2020-06-17|Novo Nordisk A/S|An injection needle assembly for an injection device and an injection device comprising such assembly|

---

CA2990950A1|2015-06-30|2017-01-05|Kaleo, Inc.|Auto-injectors for administration of a medicament within a prefilled syringe|

---

EP3319664B1|2015-07-10|2020-12-16|ALK-Abelló A/S|An injector comprising a safety pin|

---

FR3039071B1|2015-07-24|2017-07-21|Nemera La Verpilliere|AUTOMATIC LIQUID INJECTION DEVICE COMPRISING AN END SLEEVE|

---

FR3039069B1|2015-07-24|2021-07-23|Nemera La Verpilliere|AUTOMATIC LIQUID PRODUCT INJECTION DEVICE INCLUDING AN INJECTION SPRING.|

---

US10632259B2|2015-08-26|2020-04-28|Shl Medical Ag|Medicament delivery device and assembly of electronic device and the medicament delivery device|

---

EP3834865A3|2015-08-27|2021-12-29|E3D Agricultural Cooperative Association Ltd.|Reusable automatic injection device|

---

CN105457132A|2015-10-16|2016-04-06|南昌德漫多科技有限公司|Injection implementation and assisting device|

---

SG10201509159TA|2015-11-05|2017-06-29|Arrow-Med Design Pte Ltd|Injection device|

---

WO2017089276A1|2015-11-27|2017-06-01|Sanofi-Aventis Deutschland Gmbh|Medicament injection device|

---

AU2017207385B2|2016-01-12|2022-02-17|Pharma Consult Ges.M.B.H.|Injection device|

---

CN105688314A|2016-03-29|2016-06-22|中国人民解放军军事医学科学院实验仪器厂|Automatic injection device|

---

AT519383B1|2016-10-27|2018-09-15|Pharma Consult Gmbh|Injection device, in particular autoinjector, for the simultaneous delivery of several drugs|

---

CN110035786A|2016-12-02|2019-07-19|诺和诺德股份有限公司|Pre-filled type injection device with wash chamber|

---

CA3046228A1|2016-12-23|2018-06-28|Kaleo, Inc.|Medicament delivery device and methods for delivering drugs to infants and children|

---

CN110382021B|2017-02-24|2021-06-01|群康生技股份有限公司|Injection propulsion mechanism with dose control|

---

CN106890034B|2017-04-05|2018-02-02|潘懿|A kind of stock injection device that automatic physical disinfection can be achieved|

---

CN107308524B|2017-08-09|2019-02-15|甘肃成纪生物药业有限公司|A kind of fast automatic injection device|

---

EP3610907A1|2017-08-09|2020-02-19|Gansu Changee Bio-pharmaceutical Co., Ltd.|Rapid and automatic syringe|

---

EP3713622A1|2017-11-21|2020-09-30|Sanofi|Drive subassembly for a drug delivery device|

---

EP3626288A1|2018-09-19|2020-03-25|Tecpharma Licensing AG|Electronic add-on module for injectors|

---

CN112315654A|2018-11-06|2021-02-05|张琦|Anti-misoperation internal-pumping external-injection type tympanic membrane puncture and intratympanic injection medical device|

---

EP3908358A1|2019-01-07|2021-11-17|Pfizer Inc.|Injection assist device|

---

US11167087B2|2019-08-09|2021-11-09|Kaleo, Inc.|Devices and methods for delivery of substances within a prefilled syringe|

---

US11266792B2|2019-10-28|2022-03-08|FGC Holdings Limited|Single use safety needle guard|

法律状态:
2019-06-17| UUP| Utility model expired|Expiry date: 20190616 |

优先权:

---

申请号 | 申请日 | 专利标题

---

AT0095808A|AT506690B1|2008-06-16|2008-06-16|INJECTION DEVICE|

---

PCT/AT2009/000239|WO2009152542A1|2008-06-16|2009-06-16|Injection device|

---